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Cialis (Taffrail) CAS NO.171596-29-5 CAS NO.171596-29-5
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- Cialis
- (Taffrail)
- (Taffrail)
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- ProName: Cialis (Taffrail) CAS NO.171596-29-5
- CasNo: 171596-29-5
- Application: treatment of penile erectile dysfunct...
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Name: Cialis
CAS No.: 171596-29-5
Formula: C22H19N3O4
Molecular Weight: 389.40
Synonyms: Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione,6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R-trans)-;(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;GF 196960;Tadalafil [USAN];Tildenafil;Calais;(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione;Adcirca;
Density: 1.51 g/cm3
Melting Point: 298-300 °C
Boiling Point: 679.1 °C at 760 mmHg
Flash Point: 364.5 °C
Appearance: white to off-white cyrstalline powder.
Solubility:insoluble in water and alcohol.
Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) – compared to sildenafil (4.0–5.0 hours) and vardenafil (4.0–5.0 hours) – resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.